Pharmaceutical compositions comprising sorbitan esters

摘要

The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.

主权项

1. A pharmaceutical composition comprising:
(a) compound of Formula (III) or (IV):  wherein R3 is—CH2OC(O)R1, —CH2OC(O)OR1, —CH2OC(O)N(R1)2 or —C(O)R1; R4 is—CH2OC(O)R1, —CH2OC(O)OR1, —CH2OC(O)N(R1)2 or —C(O)R1; wherein each R1 is independently selected from the group consisting of hydrogen, substituted or unsubstituted aliphatic, and substituted or unsubstituted aryl; and wherein Y⊖is a pharmaceutically acceptable counterion; (b) sorbitan laurate; (c) polysorbate 20; and (d) an aqueous vehicle wherein the composition forms an aqueous, flocculated, injectable suspension.