Alpha adreneric receptor agonists for treatment of degenerative disc disease

摘要

Effective treatments of pain and/or inflammation from degenerative disc disease and/or facet joint are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a degenerative disc and/or facet joint, one can reduce, prevent or treat pain and/or inflammation caused by the degenerative disc disease and/or facet joint.

主权项

1. A method of treating pain and/or inflammation from a degenerative disc and/or facet joint in a patient in need of such treatment, the method comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of an alpha adrenergic agonist at or near the degenerative disc and/or facet joint, the one or more biodegradable drug depots comprising a biodegradable polymer comprising poly (lactide-co-glycolide) (PLGA), polylactide (PLA), polyglycolide (PGA), D-lactide, D,L-lactide, L-lactide, D,L-lactide-caprolactone, D,L-lactide-glycolide-caprolactone or a combination thereof, and having an inherent viscosity from about 0.45 dL/g to about 0.55 dL/g, wherein the drug depot releases an effective amount of the alpha adrenergic agonist over a period of at least 1 day.