发明名称 |
RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN MICE |
摘要 |
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments. Methods for making antibody sequences that bind an antigen (e.g., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments, at the endogenous immunoglobulin heavy chain locus. |
申请公布号 |
SG10201602904V(A) |
申请公布日期 |
2016.05.30 |
申请号 |
SG10201602904V |
申请日期 |
2012.10.17 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MACDONALD, LYNN;MCWHIRTER, JOHN;GURER, CAGAN;HOSIAWA, KAROLINA, A.;MURPHY, ANDREW, J. |
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