发明名称 |
5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) -(BACE) 56--2H-[14]-3-- |
摘要 |
The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta-amyloid. |
申请公布号 |
HK1182098(A1) |
申请公布日期 |
2016.05.27 |
申请号 |
HK20130109367 |
申请日期 |
2013.08.09 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
TRABANCO-SUREZ, ANDRS, AVELINO;ROMBOUTS, FREDERIK, JAN, RITA;TRESADERN, GARY, JOHN;VAN GOOL, MICHIEL, LUC, MARIA;MACDONALD, GREGOR, JAMES;MARTINEZ LAMENCA, CAROLINA;GIJSEN, HENRICUS, JACOBUS, MARIA |
分类号 |
C07D;A61K;A61P |
主分类号 |
C07D |
代理机构 |
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