METHOD OF PRODUCING pan-CDK INHIBITORS OF FORMULA (I), AND INTERMEDIATE COMPOUNDS FOR PRODUCTION THEREOF

摘要

FIELD: chemistry.SUBSTANCE: invention relates to a novel method for producing pan-CDK inhibitors (cyclin-dependent kinase) of general formula (I). Compounds of general formula (I), where Ris (C-C)-alkyl group or (C-C)-cycloalkyl ring, are obtained by connection of the previously obtained compounds (I-7-A) to (I-4-R) in the presence of benzenesulphonic acid as a catalyst, with resulting salts of benzenesulphonic acid (BSA) protected phenyl amine pyrimidine of formula (I-8-R-BSA), with removal of protective groups in the salts of formula (I-8-R-BSA) by hydrogenation in the presence of palladium on active carbon in methanol and treatment with potassium carbonate in methanol to obtain compounds of formula (I). Invention also relates to novel intermediate compounds of structural formulae (I-8-A-R-BSA) and (I-11-A-R-D-Tol-Tart).,.EFFECT: method simplifies conditions for production of intermediate and end products, which allows its use on an industrial scale.7 cl, 2 tbl