MODULAR PLATFORM FOR MULTI-TISSUE INTEGRATED CELL CULTURE

摘要

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

主权项

1. A device comprising:
a fluid routing plate comprising:
a plurality of displacement chambers; andat least one fluid flow channel coupled to each of the plurality of displacement chambers; and a control plate coupled to the fluid routing plate and comprising a plurality of actuators, wherein each of a first subset of the plurality of actuators align with each of the plurality of displacement chambers to form displacement pumps.