DETECTING REPLICATION CATASTROPHE IN CELLS

摘要

The present invention relates to methods for determining the status in a cell. In particular the present invention relates to methods for determining whether a cell population will undergo replication catastrophe in response to a cancer therapy. Further aspects relate to methods for classification of a compound of interest based on said compounds effect on amounts of DB-RPA and DNA damage in a cell nucleus. The invention also relates to methods of treatment of cancer.