ANTIBACTERIAL AGENT

摘要

An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R1 and R4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R2 and R3 represents hydrogen atom or hydroxyl group; R5 represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R1′ and R5′ represents hydrogen atom; R2′ and R3′ represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R4′ represents hydrogen atom or hydroxyl group).;

主权项

1. A prophylactic and/or therapeutic method of treatment for an infectious disease caused by a bacterium that has acquired resistance to quinolones, the method comprising administering as an active ingredient an antibacterial agent comprising a compound represented by the following general formula (I): wherein, R1 represents a hydrogen atom, a hydroxyl group, or a lower alkoxy group; R2 represents a hydrogen atom or hydroxyl group; R3 represents a hydrogen atom or a hydroxyl group; R4 represents a hydrogen atom, a hydroxyl group, or a lower alkoxy group; R5 represents a hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R1′ represents a hydrogen atom; R2′ represents a hydrogen atom, hydroxyl group, or a lower alkoxy group; R3′ represents a hydrogen atom, a hydroxyl group, or a lower alkoxy group; R4′ represents a hydrogen atom or a hydroxyl group; and R5′ represents a hydrogen atom, to a subject in need thereof.