发明名称 |
Procedimiento de desprotección mejorado para la síntesis de compuestos oligoméricos |
摘要 |
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants. |
申请公布号 |
ES2296372(T5) |
申请公布日期 |
2016.05.26 |
申请号 |
ES19990307066T |
申请日期 |
1999.09.06 |
申请人 |
Ionis Pharmaceuticals, Inc. |
发明人 |
Ravikumar, Vasulinga T.;Manoharan, Muthiah;Capaldi, Daniel C.;Krotz, Achim;Cole, Douglas L.;Guzaev, Andrei |
分类号 |
C07H21/00;C07H21/04;C07H21/02;C12Q1/68 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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