发明名称 |
RNAi Agent for Inhibition of Chikungunya Virus |
摘要 |
Provided herein are RNAi agents for inhibition of Chikungunya virus. The present disclosure provides RNAi agents for inhibition of Chikungunya virus, particularly by targeting the E2 gene and nsP1 gene or both of the Chikungunya virus; the RNAi agents comprising of the entire nucleotide sequence set forth is SEQ ID 1 or SEQ ID 5 or combination thereof; or comprising of 15 or more contiguous nucleotides as set forth is SEQ ID 1 or SEQ ID 5 or combination thereof along with the addition nucleotides from the contiguous region of the E2 and nsP1 target gene. The invention further provides a RNAi composition for reducing the E2 protein and nsP1 protein level of Chikungunya virus and inhibition of Chikungunya virus replication. The combination of RNAi agents provides an excellent therapeutic composition for treatment of Chikungunya virus infection. |
申请公布号 |
US2016145621(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
US201414899135 |
申请日期 |
2014.07.02 |
申请人 |
INDIAN COUNCIL OF MEDICAL RESEARCH |
发明人 |
Parashar Deepti;Arankalle A. Vidya;Paingankar S. Mandar;Kumar Satyendra;Gokhale D. Mangesh;Sudeep B. A.;Shinde S. Sapna |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
New Dlhi IN |