发明名称 |
MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF |
摘要 |
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease. |
申请公布号 |
US2016145609(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
US201514592737 |
申请日期 |
2015.01.08 |
申请人 |
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
OLSON ERIC N.;VAN ROOIJ EVA |
分类号 |
C12N15/113;A61L31/16;A61L31/08 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
AUSTIN TX US |