| 发明名称 |
2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF |
| 摘要 |
Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR). |
| 申请公布号 |
WO2016080853(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
WO2015PT50010 |
申请日期 |
2015.11.20 |
| 申请人 |
BSIM2 – BIOMOLECULAR SIMULATIONS LDA |
发明人 |
PONTES MEIRELES FERREIRA DE BRITO, RUI MANUEL;VIEIRA SIMÕES, CARLOS JOSE;DE VASCONCELOS DIAS DE PINHO MELO, TERESA MARGARIDA;DA SILVA VICTOR, BRUNO LOURENÇO;LOURENÇO DE ALMEIDA, ZAIDA CATARINA;CABRAL LOPES, ANA LUCIA;OLIVEIRA NASCIMENTO, BRUNO FILIPE |
| 分类号 |
C07D277/34;A61K31/426;A61P25/28;C07D277/36 |
主分类号 |
C07D277/34 |
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