| 发明名称 |
SUBSTITUTED TRIAZOLES USEFUL AS Axl INHIBITORS |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound useful in inhibiting the activity of receptor protein tyrosine kinase Axl.SOLUTION: This invention relates to substituted triazoles expressed by formula (1) and a pharmaceutical composition comprising the compounds. (R1, R4 and R5 are each independently H, alkyl, aryl, aralkyl, -C(O)R8 or -C(O)N(R6)R7; R2 is aryl substituted by one or more substituents; and R3 is aryl or heteroaryl.)SELECTED DRAWING: None |
| 申请公布号 |
JP2016094431(A) |
申请公布日期 |
2016.05.26 |
| 申请号 |
JP20150237104 |
申请日期 |
2015.12.04 |
| 申请人 |
RIGEL PHARMACEUTICALS INC |
发明人 |
DANE GOFF;ZHANG JING;SYLVAIN CATHERINE;SINGH RAJINDER;SACHA HOLLAND;YU JIAXIN;THILO HECKRODT;DING PINGYU |
| 分类号 |
C07D249/14;A61K31/4196;A61K31/428;A61K31/4355;A61K31/4365;A61K31/4375;A61K31/4439;A61K31/454;A61K31/496;A61K31/497;A61K31/498;A61K31/501;A61K31/502;A61K31/5025;A61K31/506;A61K31/517;A61K31/519;A61K31/5377;A61P3/10;A61P9/00;A61P9/10;A61P13/12;A61P15/00;A61P17/06;A61P19/02;A61P19/10;A61P27/02;A61P27/12;A61P29/00;A61P35/00;A61P35/02;A61P43/00;C07D401/04;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D417/04;C07D471/04;C07D491/048;C07D495/04;C07D495/14 |
主分类号 |
C07D249/14 |
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