| 摘要 |
The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.; |
| 主权项 |
1. A compound of formula (I): wherein: X is N or CR3; Y is N or CR4; with the proviso that not both X and Y are N; A is a bicyclic 9-membered heteroaryl comprising two or three heteroatoms independently selected from N or O, wherein A can be optionally substituted with one, two or three R5; B is a saturated or partially unsaturated mono- or bicyclic 4 to 9-membered heterocycloalkyl comprising one or two ring nitrogen atoms, the remaining ring atoms being carbon, wherein B can be optionally substituted with one, two or three R6; R1 is hydrogen, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C1-7-haloalkoxy; R2 is hydrogen, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C1-7-haloalkoxy; R3 is hydrogen, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C1-7-haloalkoxy; R4 is hydrogen, halo, C1-7-alkyl, C1-7-haloalkyl, C1-7-alkoxy or C1-7-haloalkoxy; each R5 is independently selected from halo, cyano, C1-7-alkyl, C1-7-haloalkyl or C3-7-cycloalkyl; each R6 is independently selected from C1-7-alkyl, or two R6 together form a C2-7-alkylene; or a pharmaceutically acceptable salt thereof. |
