| 主权项 |
1. A compound according to formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt thereof, wherein:
ring A is independently selected from the group consisting of: C3-10 carbocycle and 5- to 10-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, each optionally substituted with one or more R1 as valence allows; ring B is 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O and S(O)p, and optionally substituted with one or more R2 as valence allows; ring C is independently selected from the group consisting of: phenyl and 5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of N, NR6, O, and S(O)p and optionally substituted with one or more R5 as valence allows; Q is independently selected from the group consisting of: C, CH, and N; ---- is an optional bond; provided when Q is N, the optional bond is absent; R1 is independently selected from the group consisting of: H, halo, NO2, OH, CN, C1-6 alkyl, C1-4 alkoxy, —CHF2, —CF3, —CH2NH2, —OCHF2, —CO(C1-4 alkyl), —CONH2, —COOH, and 5- to 7-membered heterocycle; R2 is independently selected from the group consisting of: H, ═O, OH, NH2, CF3, halo, C1-4 alkyl (optionally substituted with OH), C1-3 alkoxy, and C(O)C1-3 alkyl; R3 is independently selected from the group consisting of: C1-6 alkyl substituted with 1-3 R3a, C3-10 carbocycle substituted with 1-3 R3a, and 5-10 membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from N, NR7, O, and S(O)p; wherein said heterocycle is substituted with 1-3 R3a; R3a is independently selected from the group consisting of: H, halogen, C1-4 alkyl, —OH, ═O, —CH2OH, C1-4 alkoxy, —CN, —NH2, —NH(C1-4 alkyl), —N(C1-4 alkyl)2, —CO2H, —CH2CO2H, —CO2(C1-4 alkyl), —CH2CO2(C1-4 alkyl), —CO2—C1-4 alkylene-O(C1-4 alkyl), —CO2—C1-4 alkylene-N(C1-4 alkyl)2, —CO2—C1-4 alkylene-O—C1-4 alkylene-N(C1-4 alkyl)2, —CO2—C1-4 alkylene-O—C1-4 alkylene-O(C1-4 alkyl), —CONH2, —CONH(C1-6 alkyl), —CON(C1-4 alkyl)2, —CONH—C1-4 alkylene-CO2(C1-4alkyl), —CONHCO2C1-4 alkyl, —CONH—C1-4alkylene-NHCO(C1-4 alkyl), —CONH—C1-4 alkylene-CONH2, —NHCOC1-4 alkyl, —NHCO2(C1-4 alkyl), Rc, —CONHRc, and —CO2Rc; R4 is independently selected from the group consisting of: H, halo, and C1-4 alkyl; R5 is independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 1-2 Rb, C2-4 alkenyl substituted with 1-2 Rb, C2-4 alkynyl substituted with 1-2 Rb OH, CN, NH2, —NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-4 alkoxy, —OCO(C1-4 alkyl), —O—C1-4 alkylene-O(C1-4 alkyl), —O—C1-4 alkylene-N(C1-4 alkyl)2, —CO2H, —CO2(C1-4 alkyl), —CONH2, —(CH2)2CONH2, —CONR9(C1-4 alkyl), —CONR9—C1-4 alkylene-O(C1-4 alkyl), —CON(C1-4 alkyl)2, —CONR9—C1-4 alkylene-N(C1-4 alkyl)2, —CON(C1-4 alkyl)-C1-4 alkylene-O(C1-4 alkyl), —CONR9—C1-4 alkylene-CO2(C1-4 alkyl), —NR9CO2C1-4 alkyl, —NR9CO2C1-4 alkyl, —NR9CONH(C1-4 alkyl), —NR9CONR9—C1-4 alkylene-CO2C1-4 alkyl, —NR9—C1-4 alkylene-OH, —NR9—C1-4 alkylene-N(C1-4 alkyl)2, R8, —OR8, —O—C1-4 alkylene-R8, —COR8, —CO2R8, —CONR9R8, —NR9COR8, —NR9R8, —NR9CO2R8, and —NR9CONR9R8; R6 is independently selected from the group consisting of: H, C1-4 alkyl, COC1-4 alkyl, CO2C1-4 alkyl, CO2Bn, phenyl, and benzyl; R7 is independently selected from the group consisting of: H and C1-4 alkyl; R8 is independently selected from the group consisting of: —(CH2)n—C3-10 carbocycle and —(CH2)n-5- to 10-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NRa, O, and S(O)p; wherein said carbocycle or heterocycle is substituted with 1-3 Rb; R9 is independently selected from the group consisting of: H and C1-4alkyl; Ra is independently selected from the group consisting of: H, C1-4 alkyl substituted with 1-2 Rd, —(CH2)nOH, CO(C1-4 alkyl), COCF3, CH2CF3, CO2(C1-4 alkyl), —CONH2, —CONH—C1-4alkylene-CO2(C1-4 alkyl), C1-4 alkylene-CO2(C1-4 alkyl), Rc, CO2Rc, and CONHRc; Rb is independently selected from the group consisting of: H, ═O, halo, CN, OH, NO2, C1-4 alkyl substituted with 1-2 Rd, C1-4 alkoxy, OCF3, —(CH2)nNH2, —(CH2)nN(C1-4 alkyl)2, CO(C1-4 alkyl), CO(C1-4 haloalkyl), CO2(C1-4 alkyl), —(CH2)n—CONH2, —(CH2)n—CONH(C1-4 alkyl), —(CH2)n—CON(C1-4 alkyl)2, —CONH—C1-4 alkylene-O(C1-4 alkyl), —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —NHCO(C1-4 alkyl), —NHCO2(C1-4 alkyl), —S(O)2NH2, —S(O)2NH(C1-4alkyl), S(O)2N(C1-4 alkyl)2, Rc, CORc, CO2Rc, —S(O)2NH(C1-4alkyl)Rc, NHCONHRc, and CONHRc; optionally, Rb and Rb together with the carbon atom(s) to which they are both attached form a 5-6 membered heterocyclic ring containing carbon atoms and 1-4 heteroatoms selected from NRa, O, and S(O)p; wherein said heterocycle is optionally substituted with ═O; or Ra and Rb are combined to form a 5-6 membered heterocyclic ring containing carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, and optionally substituted with 1-3 Re; Rc is independently selected from the group consisting of: —(CH2)n—C3-6 cycloalkyl, —(CH2)n-phenyl, and —(CH2)n-5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p; wherein each ring moiety is substituted with 1-3 Rd; Rd is independently selected from the group consisting of: H, ═O, halo, —OH, C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-8 alkoxy optionally substituted with OH, and —NHCO(C1-4 alkyl), and heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p; Re is independently selected from the group consisting of: H, halo, C1-4 alkyl, C1-4 alkoxy, OCF3, NH2, NO2, N(C1-4alkyl)2, CO(C1-4 alkyl), CO(C1-4 haloalkyl), CO2(C1-4 alkyl), CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —NHCO2(C1-4 alkyl), —(CH2)n—C3-6 cycloalkyl, —(CH2)n-phenyl, and —(CH2)n-5- to 6-membered heterocycle; n is independently selected from 0, 1, 2, 3, and 4; and p is independently selected from 0, 1, and 2. |
