发明名称 |
COMPOSITIONS AND METHODS FOR USE IN DIAGNOSIS OF ALZHEIMER'S DISEASE |
摘要 |
Provided are compositions and methods useful in the diagnosis of Alzheimer's Disease (AD). The methods involve immunologically testing biological samples for an amount of high molecular weight kininogen (HK) and cleaved high molecular weight kininogen (HKc), wherein determining less HK relative to a normal control, or determining more HKc relative to a normal control, or a combination thereof, aids in diagnosis of AD. Hybridomas and monoclonal antibodies produced by them are also provided. The monoclonal antibodies bind with specificity to either HK alone, or to both HK and HKc. Kits for use in immunological AD testing using the mAbs are also provided. |
申请公布号 |
WO2016081413(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
WO2015US60996 |
申请日期 |
2015.11.17 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
ZAMOLODCHIKOV, DARIA;STRICKLAND, SIDNEY |
分类号 |
G01N33/53;C07K7/08;G01N33/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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地址 |
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