发明名称 |
Formulations comprising cyclosporin A |
摘要 |
A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel- forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon. |
申请公布号 |
AU2014345542(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
AU20140345542 |
申请日期 |
2014.11.07 |
申请人 |
SIGMOID PHARMA LIMITED |
发明人 |
COULTER, IVAN;AVERSA, VINCENZO;ROSA, MONICA |
分类号 |
A61K9/50;A61K38/13 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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