| 摘要 |
PROBLEM TO BE SOLVED: To provide a novel α-substituted glycine amide derivative, or a pharmaceutical composition containing pharmacologically acceptable salt thereof, and a medicinal use thereof.SOLUTION: The present invention provides a compound expressed by a general formula (I) having TRPM8 inhibitory action (in the formula, Adenotes Caryl or the like, Adenotes Caryl or the like, X denotes CH or the like, Y denotes -CRR- or the like, Rand Rdenote hydrogen atom or the like independently, Rand Rdenote halogen atom or the like independently, and n denotes 1 or 2), or a pharmaceutical composition containing pharmacologically acceptable salt thereof. Furthermore, a pharmaceutical composition of the present invention is usable as treatment or a prophylactic drug of disease or symptom caused by hyperexcitement or disorder of afferent nerves.SELECTED DRAWING: None |
