| 发明名称 |
METHOD FOR DETERMINING FREE COPPER |
| 摘要 |
The present invention relates to a new method for the determination of ‘free’ copper concentration in serum, i.e. the portion of serum copper not structurally bound to ceruloplasmin. The present invention also refers to a method with a high degree of sensitivity and precision for the determination of free copper in serum samples of patients with Alzheimer's disease. |
| 申请公布号 |
US2016146841(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201414888088 |
申请日期 |
2014.04.29 |
| 申请人 |
CANOX4DRUG S.P.A. |
发明人 |
COLABUFO Nicola Antonio;BERARDI Francesco;LEOPOLDO Marcello;PERRONE Roberto;SQUITTI Rosanna |
| 分类号 |
G01N33/84;G01N33/52;G01N31/22 |
主分类号 |
G01N33/84 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An in vitro method for determining the concentration of free copper in a serum sample comprising the following steps:
(a) loading said serum sample on a resin for solid phase extraction to obtain a bonded fraction and an eluted fraction comprising free copper; and (b) determining the concentration of free copper in the fraction eluted in step (a) using a coumarin fluorescent probe. |
| 地址 |
Capurso BA IT |
