AGENTS DERIVED FROM HOLOPTELEA INTEGRIFOLIA AND THEIR COMPOSITIONS FOR THE CONTROL OF METABOLIC SYNDROME AND ASSOCIATED DISEASES

摘要

The invention discloses phytochemical agents derived from Holoptelea integrifolia and novel composition(s) comprising at least one component selected from the extract(s), fraction(s) and active compound(s) for the protection and alleviation of Metabolic Syndrome,' insulin resistance, endothelial dysfunction, chronic kidney disease, atherosclerosis, diabetes and other disease 'conditions associated with metabolic syndrome. The invention also dislcoses the amelioration of certain biomarker molecules such as Peroxisome proliferator-activated receptor gamma (PPAR-y), Adipose Differentiation Related Protein (ADRP), CD36, Adipocyte Fatty-acid-Binding Protein (aP2IFABP-4/A~FABP), beta-3 Adrenergic Receptor (J33AR), Leptin, Perilipin and Adiponectin by using the phytochemical components, derived from Holoptelea integri folia.