Methods for Predicting Responses to Chemical or Biological Substances

摘要

Methods for predicting differential human responses to chemical and biological substances using extra-embryonic pluripotent or multipotent stem cells from at least 20 different donors. In one embodiment, the extra-embryonic pluripotent or multi-potent stem cells are differentiated. The method is useful for predicting and elucidating differential human responses to chemical and biological substances in vitro across a genetically diverse population.

主权项

1. A method for predicting differential responses of humans to a biological or chemical substance comprising combining the substance with extra-embryonic stem cells from at least 10 genetically different human donors in vitro, assaying for an effect on the cells, analyzing the effect on cells from each donor identifying differences in effects on the extra-embryonic stem cells from the at least 10 genetically different donors, and comparing the differences across donors, wherein the comparison of the differences in effect from each donor predicts the differential responses that the substance will have on the humans.