发明名称 CYSTOBACTAMIDES
摘要 The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections:;
申请公布号 US2016145304(A1) 申请公布日期 2016.05.26
申请号 US201414904654 申请日期 2014.07.14
申请人 HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH ;GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER 发明人 Baumann Sascha;Herrmann Jennifer;Mohr Kathrin;Steinmetz Heinrich;Gerth Klaus;Raju Ritesh;Müller Rolf;Hartmann Rolf;Hamed Mostafa;Elgaher Walid A.M.;Moreno Maria;Gille Franziska;Wang Liang Liang;Kirschning Andreas
分类号 C07K7/06;C07K5/065 主分类号 C07K7/06
代理机构 代理人
主权项 1. A compound of formula (V) wherein R51 is a hydrogen atom, or a C1-6 alkyl group; R52 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; R53 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; R54 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; R55 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; D is N or CR56; E is N or CR57; G is N or CR58; M is N or CR59; R56 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; R57 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; R58 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; R59 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; and Ar6 is an optionally substituted phenyl group or an optionally substituted heteroaryl group having 5 or 6 ring atoms including 1, 2, 3 or 4 heteroatoms selected from oxygen, sulphur and nitrogen; or a pharmaceutically acceptable salt, solvate or hydrate or a pharmaceutically acceptable formulation thereof.
地址 Braunschweig DE