CONSENSUS PROSTATE ANTIGENS, NUCLEIC ACID MOLECULE ENCODING THE SAME, AND VACCINE AND USES COMPRISING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a consensus prostate antigen, to provide a nucleic acid molecule encoding the same, and to provide a vaccine and uses comprising the same.SOLUTION: Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.SELECTED DRAWING: None