发明名称 |
COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS |
摘要 |
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions. |
申请公布号 |
US2016143960(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
US201514955532 |
申请日期 |
2015.12.01 |
申请人 |
The University of Tokyo |
发明人 |
Honda Kenya;Atarashi Koji;Itoh Kikuji;Tanoue Takeshi |
分类号 |
A61K35/74;A61K9/00 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition, comprising a purified bacterial mixture of at least two live bacterial strains belonging to Clostridium clusters IV and XIVa, wherein the bacterial mixture induces proliferation and/or accumulation of regulatory T cells. |
地址 |
Tokyo JP |