Intensity Correction for TOF Data Acquisition

摘要

Systems and methods are provided for correcting uniform detector saturation of a mass analyzer using a calibration curve. In one method, a measured spectrum is received from a mass analyzer that includes a detector and an analog-to-digital converter (ADC) detector subsystem and that analyzes a beam of ions produced by an ion source that ionizes molecules of a sample using a processor. A total ion value of the measured spectrum is calculated by summing intensities of ions in the measured spectrum using the processor. A correction factor is determined by comparing the total ion value to a stored calibration curve that provides correction factors as a function of total ion values using the processor. Intensities of the measured spectrum are multiplied by the determined correction factor producing a corrected measured spectrum using the processor.

主权项

1. A system for correcting uniform detector saturation of a mass analyzer using a calibration curve, comprising:
an ion source that ionizes molecules of a sample producing a beam of ions; and a mass analyzer that includes a detector and an analog-to-digital converter (ADC) detector subsystem analyzes the beam of ions, producing a measured spectrum; and a processor in communication with the mass analyzer that
(a) receives the measured spectrum from the mass analyzer,(b) calculates a total ion value of the measured spectrum by summing intensities of ions in the measured spectrum,(c) determines a correction factor by comparing the total ion value to a stored calibration curve that provides correction factors as a function of total ion values, and(d) multiplies intensities of the measured spectrum by the determined correction factor producing a corrected measured spectrum.