Biological Constructs for Treating Damaged Organs and Tissue

摘要

Biological constructs that can be engineered into a variety of shapes and employed to treat, augment and/or support damaged or diseased mammalian organs and/or tissue related thereto. The shapes include jackets and bands that are configured to encase a preselected region of a mammalian organ.

主权项

1. An implantable biological construct for constraining and treating a damaged mammalian heart, comprising:
a jacket comprising a first extracellular matrix (ECM) composition comprising first ECM from a first mammalian tissue source, said jacket further comprising an open proximal end, a distal end, an internal encasement surface and an exterior surface, said jacket defining an internal volume between said open proximal end and said distal end, said jacket being configured to encase a region of said heart, wherein said jacket conforms to an external geometry of said heart region, and wherein, when said heart region includes a damaged tissue region and said jacket is positioned on said heart region, said jacket induces modulated healing of said damaged tissue region, said modulated healing comprising modulated inflammation and induced neovascularization and, thereby, remodeling of said damaged tissue region, and wherein, during a cardiac cycle of said heart, said jacket concomitantly exerts a compressive force to said heart region, wherein said jacket induces adaptive regeneration of said heart, said adaptive remodeling comprising stress-induced hypertrophy.