METHOD FOR THE TARGETED KILLING OF CELLS BY NUCLEOTIDE MOLECULES THAT ARE DIRECTED TO mRNA BINDING, AND ALSO NUCLEOTIDE MOLECULES AND APPLICATION KIT FOR SUCH USE

摘要

Nucleotide molecules are used for the targeted killing of cells, which bind with a nucleotide sequence to a single region of the mRNA which, according to sequencing analyses, is statistically very rarely subject to a mutation and, thus, also in case of increased mutation rates in the whole genome, reliably kills the cell without further mRNA binding or other influence on the cell being necessary.

主权项

1. A method for the targeted killing of cells, comprising binding a nucleotide sequence of nucleotide molecules to a single selected region of mRNA of the cells, the selected region being a region which, according to sequencing analyses, is statistically only very rarely subject to mutation, whereby the cells are reliably killed without further mRNA binding or other influence on the cell being necessary and without regard to the mutation rate of the whole genome of the cells.