发明名称 |
COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS, OR PROCESSES CHARACTERIZED BY ABERRANT FIBROBLAST PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITION |
摘要 |
The described invention provides compositions and methods for reducing progression of a fibrosis in a tissue of a subject selected from liver, kidney or vascular fibrosis, the progression of the fibrosis being characterized by aberrant fibroblast proliferation and extracellular matrix deposition in the tissue. The method includes administering a therapeutic amount of a pharmaceutical composition containing a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the polypeptide is effective to reduce progression of the fibrosis, to treat remodeling of the tissue, or a combination thereof. |
申请公布号 |
WO2016081475(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
WO2015US61118 |
申请日期 |
2015.11.17 |
申请人 |
MOERAE MATRIX, INC. |
发明人 |
LANDER, CYNTHIA;BROPHY, COLLEEN |
分类号 |
A61K38/16;A61K31/573;A61K38/08;A61K38/10;A61P29/00;A61P35/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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