发明名称 |
NOVEL Th1-INDUCING ADJUVANT COMPRISING COMBINATION OF DIFFERENT NUCLEIC ACID ADJUVANTS, AND USE OF SAME |
摘要 |
The present invention provides the induction of novel Th1 response, the induction of cytotoxic T cells and anti-cancer/anti-allergic activity techniques. Provided is a combination of a CpG oligonucleotide and an STING agonist. Also provided is a composition which contains an STING agonist, can be used as a type-I adjuvant, and is characterized in that the STING agonist is administered together with a CpG oligonucleotide. Further provided is an anti-cancer agent comprising a CpG oligonucleotide and is characterized in that the CpG oligonucleotide is administered together with an STING agonist. Still further provided is a composition which contains a CpG oligonucleotide and can be used for reducing or eliminating the IgE-inducing activity of an STING agonist. |
申请公布号 |
WO2016079899(A1) |
申请公布日期 |
2016.05.26 |
申请号 |
WO2015JP01564 |
申请日期 |
2015.03.20 |
申请人 |
NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION |
发明人 |
ISHII, KEN;KURODA, ETSUSHI;TEMIZOZ, BURCU |
分类号 |
A61K48/00;A61K31/7076;A61K31/708;A61K31/7088;A61K39/39;A61K45/00;A61P35/00;A61P37/04;A61P43/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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