发明名称 |
Tetraspanin CD82 as a diagnostic and/or therapeutic module for xenograft recognition and/or rejection |
摘要 |
The present invention relates to CD82 polypeptides of the mammalian tetraspanin CD82 protein family for use in the diagnosis, prevention and/or treatment of xenograft recognition and/or rejection. The present invention furthermore relates to CD82 knockout and transgenic animals and their cells, tissues and organs. The present invention furthermore relates to antibodies against a CD82 polypeptide, pharmaceutical compositions comprising at least one inhibitor of a CD82 polypeptide or comprising cells, tissues and organs of animals in which the CD82 level, expression and/or activity is modified, and their use in the diagnosis, prevention and/or treatment of xenograft recognition and/or rejection. The present invention furthermore relates to methods of diagnosing xenograft recognition and/or rejection and methods for the prevention and/or treatment of xenograft recognition and/or rejection as well as methods of xenotransplantation. |
申请公布号 |
EP2708234(B1) |
申请公布日期 |
2016.05.25 |
申请号 |
EP20120184067 |
申请日期 |
2012.09.12 |
申请人 |
KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTRE |
发明人 |
AL-MOHANNA, FUTWAN;SALEH, SOAD;PARHAR, RANJIT;AL-HEJAILAN, REEM;BEKHEET, RAZAN;COLLISON, KATE |
分类号 |
A61K38/17;A01K67/027;A61P37/06;C07K14/705;C07K16/18;C07K16/28;G01N33/50 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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