发明名称 |
CYTOTOXIC ANTIBODY DIRECTED AGAINST TYPE B LYMPHOID HEMATOPOIETIC PROLIFERATIONS |
摘要 |
The present invention relates to a monoclonal antibody directed against the CD20 antigen, wherein the variable region of each of the light chains thereof is encoded by a sequence which shares at least 70% identity with murine nucleic acid sequence SEQ ID No. 5, the variable region of each of the heavy chains thereof is encoded by a sequence which shares at least 70% identity with murine nucleic acid sequence SEQ ID No. 7, and the constant regions of light and heavy chains thereof are constant regions from a non-murine species, as well as for activation of FcγRIIIA receptors in immune effector cells, and for the manufacture of a drug especially for the treatment of leukaemia or lymphoma. |
申请公布号 |
EP1824887(B1) |
申请公布日期 |
2016.05.25 |
申请号 |
EP20050825974 |
申请日期 |
2005.12.14 |
申请人 |
LABORATOIRE FRANÇAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES |
发明人 |
DE ROMEUF, CHRISTOPHE;GAUCHER, CHRISTINE;TEILLAUD, JEAN-LUC;PROST, JEAN-FRANÇOIS |
分类号 |
C07K16/28;A61K39/395;A61P35/02;A61P37/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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