THREE-DIMENSIONAL SCAFFOLD FUNCTIONALIZED WITH MICRO-TISSUES FOR TISSUE REGENERATION

摘要

The present invention concerns a biomaterial devoid of a growth factor, comprising: - a three-dimensional scaffold made of a biocompatible polymer; and - living cells, wherein said living cells are in form of microtissues and the nanofibrous three- dimensional scaffold is a nanofibrous scaffold. It further concerns a method for manufacturing such a biomaterial. Finally, it concerns such a biomaterial for use in the treatment of a bone and/or cartilage defect.