COMPOSITIONS AND METHODS FOR MODULATING APOA1 AND ABCA1 EXPRESSION
摘要
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of APOA1 or ABCA1. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of APOA1 or ABCA1. Methods for modulating expression of APOA1 or ABCA1 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of APOA1 or ABCA1.
申请公布号
EP2849801(A4)
申请公布日期
2016.05.25
申请号
EP20130790940
申请日期
2013.05.16
申请人
RANA THERAPEUTICS INC.;THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL
发明人
KRIEG, ARTHUR, M.;SUBRAMANIAN, ROMESH;MCSWIGGEN, JAMES;LEE, JEANNIE, T.