摘要 |
The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is specifically delivered to target cells. Preferably, said modified cytokine is a single chain variant of the TNF superfamily, even more preferably, one or more of the chains carry one or more mutations, resulting in a low affinity to the receptor, wherein said mutant cytokine is specifically delivered to target cells. The targeting is realized by fusion of the modified cytokine of the TNF superfamily to a targeting moiety, preferably an antibody or antibody-like molecule. The invention relates further to the use of such targeted modified cytokine of the TNF superfamily to treat diseases. |
申请人 |
VIB VZW;UNIVERSITEIT GENT;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITÉ MONTPELLIER 2;CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER |
发明人 |
TAVERNIER, JAN;BULTINCK, JENNYFER;PEELMAN, FRANK;UZÉ, GILLES |