发明名称 |
COMPOSITIONS AND METHODS OF DETECTING AND TREATING NEURAL TUBE DEFECTS |
摘要 |
The present invention generally relates to compositions, reagents and methods for detecting and treating a neural tube defect in a fetus. One aspect of the invention provides a method including administrating a composition containing noggin or LDN-193189 to the fetus in utero. In certain embodiments, the composition is administrated if the maternal blood or amniotic fluid contains an elevated amount of BMP4 and/or a reduced amount of noggin. In another aspect of the invention, the method includes administrating a composition containing GDC-0449 to the fetus in utero. In certain embodiments, the GDC-0449 is administrated if the maternal blood or amniotic fluid contains an elevated amount of sonic hedgehog. |
申请公布号 |
EP3021945(A1) |
申请公布日期 |
2016.05.25 |
申请号 |
EP20140826462 |
申请日期 |
2014.07.15 |
申请人 |
ANN AND ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO |
发明人 |
MAYANIL, C. SHEKHAR;ALLENDER, ELISE;TSURUBUCHI, TAKAO;GINSBERG, NORMAN;MCLONE, DAVID G.;TOMITA, TADANORI |
分类号 |
A61P25/00 |
主分类号 |
A61P25/00 |
代理机构 |
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