摘要 |
A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of ±4²1, ±4²1, ±4²7, ±4²3 and ±L²2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal. |
申请人 |
TEXAS HEART INSTITUTE |
发明人 |
BIEDIGER, RONALD, J.;GUNDLACH, IV, WILLIAM, C.;MARKET, ROBERT, V.;SAVAGE, MICHAEL, M.;VANDERSLICE, PETER |