SYNTHESIS AND ANTICANCER ACTIVITY OF DERIVATIVES OF ARYL AND HETEROARYL QUINOLINES

摘要

FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula I and pharmaceutically acceptable salts thereof, where R is hydrogen, RO(OH), P(=O)(O-(C-C)alcylenphenyl)or P(=O)(OM); W represents 2-halogenphenyl, 3-halogenphenyl or 4-halogenphenyl; Ris (C-C)alkoxy, hydroxyl or OR; Ris hydroxyl or (C-C)alkoxy; Rrepresents hydrogen, hydroxyl or O-(C-C)alcylenphenyl; Rrepresents a RO(OH), P(=O)(O-(C-C)alcylenphenyl)or P(=O)(OM), and m is monovalent metal ion; or where R is hydrogen, RO(OH), P(=O)(O-(C-C)alcylenphenyl)or P(=O)(OM); W represents 2-halogenphenyl, 3-halogenphenyl or 4-halogenphenyl; Rrepresents hydrogen, (C-C)alkoxy, hydroxyl or OR; Ris (C-C)alkoxy; Ris hydroxyl or O-(C-C)alcylenphenyl; Rrepresents PO(OH), P(=O)(O-(C-C)alcylenphenyl)or P(=O)(OM), and m is monovalent metal ion. Disclosed compounds have anti-cancer activity. Invention also relates to compounds of formula I, radicals of which are presented in patent claim and to using pharmaceutical composition containing effective amount of compound of invention for treating cancer.EFFECT: technical outcome is new compounds possessing anticancer activity.17 cl, 23 dwg, 7 tbl, 4 ex