FORMULATION FOR BISPECIFIC T-CELL ENGAGERS (BITES) T(BITES)
摘要
The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.
申请公布号
HK1211215(A1)
申请公布日期
2016.05.20
申请号
HK20150112055
申请日期
2015.12.08
申请人
BAYER PHARMA AKTIENGESELLSCHAFT
发明人
OLBRICH, CARSTEN;BUNTE, THOMAS;WINTER, JONAS;PETERS, JRG;TRILL, THOMAS