发明名称 |
METHODS, APPARATUS AND SYSTEMS FOR PRODUCTION, COLLECTION, HANDLING, AND IMAGING OF TISSUE SECTIONS |
摘要 |
Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). Thin tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples. |
申请公布号 |
US2016139007(A1) |
申请公布日期 |
2016.05.19 |
申请号 |
US201615005431 |
申请日期 |
2016.01.25 |
申请人 |
President and Fellows of Harvard College |
发明人 |
Hayworth Kenneth Jeffrey;Hayworth Amy Au |
分类号 |
G01N1/06 |
主分类号 |
G01N1/06 |
代理机构 |
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代理人 |
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主权项 |
1. An apparatus for processing a tissue sample, the apparatus comprising:
a support tape having a surface upon which to support a thin tissue section, the support tape adapted for electron microscopy; a conveyor portion constructed and arranged to automatically guide the support tape having the thin tissue section disposed thereon from a first location toward a second location; and a collection portion for collecting the support tape and the thin tissue section from the conveyor region. |
地址 |
Cambridge MA US |