CRYSTALLINE SOLVATES AND COMPLEXES OF (1S) -1, 5-ANHYDRO-1-C-(3-((PHENYL)METHYL)PHENYL)-D-GLUCITOL DERIVATIVES WITH AMINO ACIDS AS SGLT2 INHIBITORS FOR THE TREATMENT OF DIABETES
摘要
Abstract The present invention relates to crystal forms of the compound of the formula I including complexes tmeof wherein the complex is formed as a co-crystal forn with proline or phenylaianine. The invention also discloses processes of ornming the crystal fons of formMla I and methods of treating diseases such as diabetes, glucose intolerance, insulin resistance and other conditions using such structures. OEt HO"'O
申请公布号
AU2014268177(B2)
申请公布日期
2016.05.19
申请号
AU20140268177
申请日期
2014.11.26
申请人
ASTRAZENECA AB
发明人
GOUGOUTAS, JACK Z.;LOBINGER, HILDEGARD;RAMAKRISHNAN, SRIVIDYA;DESHPANDE, PRASHANT P.;BIEN, JEFFREY T.;LAI, CHIAJEN;WANG, CHENCHI;RIEBEL, PETER;GROSSO, JOHN ANTHONY;NIRSCHL, ALEXANDRA A.;SINGH, JANAK;DIMARCO, JOHN D.