发明名称 |
MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES |
摘要 |
Provided are monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-1R binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. AntiErbB3 and anti-IGF-1R antibodies (e.g., monoclonal antibodies) are also provided. |
申请公布号 |
US2016137738(A1) |
申请公布日期 |
2016.05.19 |
申请号 |
US201514857344 |
申请日期 |
2015.09.17 |
申请人 |
Merrimack Pharmaceuticals, Inc. |
发明人 |
Baum Jason;Johnson Bryan;Lugovskoy Alexey Alexandrovich;Xu Lihui;Kohli Neeraj;Fitzgerald Jonathan Basil;Adams Sharlene |
分类号 |
C07K16/28;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Cambridge MA US |