CARDIOVASCULAR DISEASE RISK ASSESSMENT

摘要

The invention provides improved methods for analyzing cardiovascular disease risk. According to the invention, an algorithm that considers LDL and HDL subfractions, along with Lp(a) provides significant improvement in predicting CVD versus standard assays that include standard risk factors. Methods of the invention comprise measuring LDL and HDL subfractions in addition to Lp(a) without reference to standard risk factor measurements, such as CRP, total cholesterol, body mass index, weight, triglycerides, and the like. It is unexpected that an algorithm focusing only on LDL and HDL subfractions and Lp(a) would be more informative as to CVD risk than measurements that are much more comprehensive in terms of the markers that are reviewed. In particular, the sdLDL-C subfraction of LDL and the ApoA-1 in large alpha-1 HDL are most informative in conjunction with Lp(a).

主权项

1. A method for assessing cardiovascular risk, the method comprising the steps of:
obtaining a sample from a patient; conducting an assay on the sample to determine blood levels of an LDL subfraction, an HDL subfraction, and Lp(a); entering said levels into a multivariate model to produce a probability of the individual developing cardiovascular disease.