POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF

摘要

A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.

主权项

1. A polymer of formula:wherein:
each A and B is, independently, a bond; a substituted or unsubstituted, branched or unbranched, cyclic or acyclic C1-20 aliphatic; a substituted or unsubstituted, branched or unbranched, cyclic or acyclic C1-20 heteroaliphatic; substituted or unsubstituted aryl; or a substituted or unsubstituted heteroaryl; each R1 and R2 is, independently, unsubstituted, branched or unbranched, cyclic or acyclic C1-20 aliphatic; substituted or unsubstituted aryl; or a substituted or unsubstituted heteroaryl; eachmay optionally form a cyclic structure by the joining of R1 and R2;
each R3, R4, and R5 is hydrogen; a substituted or unsubstituted, branched or unbranched, cyclic or acyclic C1-20 aliphatic; a substituted or unsubstituted, branched or unbranched, cyclic or acyclic C1-20 heteroaliphatic; a substituted or unsubstituted aryl; or a substituted or unsubstituted heteroaryl; eachmay optionally form a cyclic structure;
each E and G is, independently, hydrogen; a substituted or unsubstituted, branched or unbranched, cyclic or acyclic C1-20 aliphatic; a substituted or unsubstituted, branched or unbranched, cyclic or acyclic C1-20 heteroaliphatic; substituted or unsubstituted aryl; a substituted or unsubstituted heteroaryl;n is an integer from 2 to 10,000, inclusive; or a salt thereof.