| 摘要 |
The present invention relates to compounds, compositions and methods comprising nanopartieles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that can entrap FASN inhibitor compounds. In one embodiment, the FASN inhibitor compounds include Orlistat In one embodiment, the hydrophobic moieties comprise 5-βCA, Pba, or ODA, or combinations thereof, in a variation, the present invention relates to a composition comprising MPs based upon HLA, Orlistat, one or more of the hydrophobic moieties comprising 5-βCA, Pba, or ODA, and one or more of members selected from the group consisting of PEG and -a dilute solution containing SDS. |
