| 发明名称 |
POLYETHYLENE GLYCOL BASED OLIGOMERS FOR COATING NANOPARTICLES, NANOPARTICLES COATED THEREWITH, AND RELATED METHODS |
| 摘要 |
In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety. |
| 申请公布号 |
US2016136302(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201514838586 |
申请日期 |
2015.08.28 |
| 申请人 |
THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. |
发明人 |
Mattoussi Hedi;Palui Goutam;Na Hyon Bin |
| 分类号 |
A61K49/00 |
主分类号 |
A61K49/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising:
nanoparticles surface-capped with a coating composition, the coating composition comprising: repeating polyacrylic acid monomer units covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom, wherein a first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety. |
| 地址 |
TALLAHASSEE FL US |
