| 发明名称 |
PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY |
| 摘要 |
Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity. |
| 申请公布号 |
US2016136289(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201414904385 |
申请日期 |
2014.07.09 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV ;BAYLOR COLEGE OF MEDICINE |
发明人 |
Puri Anu;Blumenthal Robert P.;Joshi Amit;Tata Darayash B. |
| 分类号 |
A61K47/48;A61N5/06;A61K9/00;A61K31/704;A61K9/127;A61K41/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A photoactivatable lipid-based nanoparticle, comprising:
a vesicle wall surrounding a cavity, the vesicle wall comprising
(i) a lipid bilayer comprising
(a) from 10 mol % to 20 mol % 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC),(b) from 3 mol % to 5 mol % 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(polyethylene glycol) (DSPE-PEG), and(c) dipalmitoylphosphatidylcholine (DPPC), and(ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer,wherein the vesicle wall has a lipid:HPPH weight ratio from 80:1 to 10:1. |
| 地址 |
Bethesda MD US |
