| 发明名称 |
Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-YL)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate |
| 摘要 |
Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described. |
| 申请公布号 |
US2016137638(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201615002163 |
申请日期 |
2016.01.20 |
| 申请人 |
Forum Pharmaceuticals, Inc. |
发明人 |
Oliver-Shaffer Patricia;Shapiro Gideon;Chesworth Richard;Kishida Muneki;Ishige Takayuki |
| 分类号 |
C07D453/02;A61K31/439;C30B29/54;A61K9/48 |
主分类号 |
C07D453/02 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A crystalline Form II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate, characterized by an x-ray powder diffraction pattern having peaks expressed as 2Θ at:
i) one or both of 21.16 and 21.38±0.20 degrees when measured against an internal silicon standard; and ii) at least four peaks selected from a group of peaks consisting of: 4.48, 9.00, 13.58, 15.62, 16.48, 19.02, 19.44, 22.46, and 25.00±0.20 degrees when measured against an internal silicon standard. |
| 地址 |
Waltham MA US |
