主权项 |
1. A compound of formula I: wherein: a is an integer from 1 to 10; R1 is H, Z, —C(═O)—CH═CH2, —(CH2—CH2—O)nH, —(CH2—CH2—CH2—O)nH, or —(CH2—CH2—O)n—(CH2—CH(CH3)—O)nH, where each n is, independently, an integer from 1 to 18; each R2 is, independently, H, Z, —C(═O)—CH═CH2, —(CH2—CH2—O)pH, —(CH2—CH2—CH2—O)pH, or —(CH2—CH2—O)p—(CH2—CH(CH3)—O)pH, where each p is, independently, an integer from 1 to 18; R3 is H, Z, —C(═O)—CH═CH2, —(CH2—CH2—O)qH, —(CH2—CH2—CH2—O)qH, or —(CH2—CH2—O)q—(CH2—CH(CH3)—O)qH, where each q is, independently, an integer from 1 to 18; R4 is —OH, —NH2, —O—Z, —N(Z)2, —N(CH2—O—Z)2, —N(CH2OH)2, —N(CH2CH2—O—Z)2, —N(CH2NH2)2, —N(CH2CH2OH)2, —CH2—O—Z, —CH2—OH, —CH2—NH2, —N(CH3)2, —O-(alkylene)-CH3, —CH2—Y, —NCO, —O—C(═O)—(CH2)r—CH3, —NH—Z, —N[CH2O—C(═O)—CH═CH2]2, —NH—C(═O)CH═CH2, —CH2CH2—O—Z, —CH2CH2OH, —O—C(═O)—CH═CH2, —N(CH2—CH2—NH2)2, —(CH2—CH2—O)rH, —(CH2—CH2—CH2—O)rH, —N[CH2—CH2—O—C(═O)—CH═CH2]2, or —N[CH2—CH2—NH—C(═O)—CH═CH2]2, where r is an integer from 1 to 18; R5 is —OH, —NH2, —O—Z, —N(Z)2, —N(CH2—O—Z)2, —N(CH2OH)2, —N(CH2CH2—O—Z)2, —N(CH2NH2)2, —N(CH2CH2OH)2, —CH2—O—Z, —CH2—OH, —CH2—NH2, —N(CH3)2, —O-(alkylene)-CH3, —CH2—Y, —NCO, —O—C(═O)—(CH2)rCH3, —NH—Z, —N[CH2O—C(═O)—CH═CH2]2, —NH—C(═O)CH═CH2, —CH2CH2—O—Z, —CH2CH2OH, —O—C(═O)—CH═CH2, —N(CH2—CH2—NH2)2, —(CH2—CH2—O)tH, —(CH2—CH2—CH2—O)tH, —N[CH2—CH2—O—C(═O)—CH═CH2]2, or —N[CH2—CH2—NH—C(═O)—CH═CH2]2, where t is an integer from 1 to 18; R6 is —OH, —NH2, —O—Z, —N(Z)2, —N(CH2—O—Z)2, —N(CH2OH)2, —N(CH2CH2—O—Z)2, —N(CH2NH2)2, —N(CH2CH2OH)2, —CH2—O—Z, —CH2—OH, —CH2—NH2, —N(CH3)2, —O-(alkylene)-CH3, —CH2—Y, —NCO, —O—C(═O)—(CH2)v—CH3, —NH—Z, —N[CH2O—C(═O)—CH═CH2]2, —NH—C(═O)CH═CH2, —CH2CH2—O—Z, —CH2CH2OH, —O—C(═O)—CH═CH2, —N(CH2—CH2—NH2)2, —(CH2—CH2—O)vH, —(CH2—CH2—CH2—O)vH, —N[CH2—CH2—O—C(═O)—CH═CH2]2, or —N[CH2—CH2—NH—C(═O)—CH═CH2]2, where v is an integer from 1 to 18; each R7 is, independently, —OH, —NH2, —O—Z, —N(Z)2, —N(CH2—O—Z)2, —N(CH2OH)2, —N(CH2CH2—O—Z)2, —N(CH2NH2)2, —N(CH2CH2OH)2, —CH2—O—Z, CH2—NH2, —N(CH3)2, —O-(alkylene)-CH3, —CH2—Y, —NCO, —O—C(═O)—(CH2)w—CH3, —NH—Z, —N[CH2O—C(═O)—CH═CH2]2, —NH—C(═O)CH═CH2, —CH2CH2—O—Z, —CH2CH2OH, —O—C(═O)—CH═CH2, —N(CH2—CH2—NH2)2, —(CH2—CH2—O)wH, —(CH2—CH2—CH2—O)wH, —N[CH2—CH2—O—C(═O)—CH═CH2]2, or —N[CH2—CH2—NH—C(═O)—CH═CH2]2, where w is an integer from 1 to 18; R8 is —OH, —NH2, —O—Z, —N(Z)2, —N(CH2—O—Z)2, —N(CH2OH)2, —N(CH2CH2—O—Z)2, —N(CH2NH2)2, —N(CH2CH2OH)2, —CH2—O—Z, —CH2—OH, —CH2—NH2, —N(CH3)2, —O-(alkylene)-CH3, —CH2—Y, —NCO, —O—C(═O)—(CH2)x—CH3, —NH—Z, —N[CH2O—C(═O)—CH═CH2]2, —NH—C(═O)CH═CH2, —CH2CH2—O—Z, —CH2CH2OH, —O—C(═O)—CH═CH2, —N(CH2—CH2—NH2)2, —(CH2—CH2—O)xH, —(CH2—CH2—CH2—O)xH, —N[CH2—CH2—O—C(═O)—CH═CH2]2, or —N[CH2—CH2—NH—C(═O)—CH═CH2]2, where x is an integer from 1 to 18; Z isand
Y is Cl, Br, F, or I. |