| 发明名称 |
PHARMACEUTICAL COMPOSITIONS FOR PREVENTING GLUCOCORTICOID-INDUCED CORNEAL OR SKIN THINNING |
| 摘要 |
The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof. |
| 申请公布号 |
US2016136183(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201414899162 |
申请日期 |
2014.06.20 |
| 申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ;UNIVERSITE PARIS DESCARTES ;UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ;ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) |
发明人 |
FARMAN Nicolette;JAISSER Frederic;BEHAR-COHEN Francine;ARACTINGI Selin;NGUYEN Van Tuan |
| 分类号 |
A61K31/585;A61K9/00 |
主分类号 |
A61K31/585 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof comprising
administering to the subject a therapeutically effective amount of a mineralocorticoid receptor antagonist, wherein said therapeutically effective amount is sufficient to prevent or reduce the glucocorticoid-induced corneal or skin thinning in the subject. |
| 地址 |
Paris FR |
