| 发明名称 |
GLYCATED HEXAPEPTIDE OXIDASE AND USE THEREOF |
| 摘要 |
The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction. |
| 申请公布号 |
US2016138073(A1) |
申请公布日期 |
2016.05.19 |
| 申请号 |
US201414898022 |
申请日期 |
2014.07.07 |
| 申请人 |
KYOWA MEDEX CO., LTD. ;KYOTO UNIVERSITY |
发明人 |
OGAWA Noriyuki;UMEHARA Fumi;KIMURA Takehide;MURATA Kousaku;HASHIMOTO Wataru |
| 分类号 |
C12Q1/26;C12Q1/37;C12N9/06 |
主分类号 |
C12Q1/26 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted with an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid. |
| 地址 |
Tokyo JP |
